NR5A1 targets a variety of genes such as CYP17, DAX-1, and STAR [9,10,11,12,13], and regulates transcription of these genes through cooperating with multiple transcription factors and cofactors, including GATA4, SOX9, EGR1, and WT1 [14,15,16,17]; however, the molecular mechanisms of NR5A1 in cancer development are still largely unknown. The gene discussed is NR5A1; the disease is cancer.