SQSTM1 and neoplasm: Figure 2G presents a Western blot showing the knockdown of Atg5 and the consequent interference with etoposide-induced degradation of p62/SQSTM1. Figure 2H shows that silencing of Atg5 did not significantly decrease the viability of senescent H460 cells (a small decrease in sensitivity was evident at the 0.25 μM concentration). As was the case with CQ and Baf, genetic autophagy inhibition failed to alter the extent of senescence (Figure 2J,K), the profile of growth arrest (Figure 2I), or the capacity of senescent tumor cells to undergo proliferative recovery (Figure 2I).