A 24-week study using Apc1638N/+ mice, which have a truncation on codon 1638 of the tumor suppressor Apc gene, found that feeding a modified AIN76A diet with half the content of vitamin D and 90% less calcium resulted in the formation of colonic adenomas and carcinomas and enhanced expression of cyclin D1 and anti-apoptotic protein Bcl-2, which are commonly overexpressed in colorectal cancer [45]. The gene discussed is CCND1; the disease is colon adenoma.