Interestingly, Bergomas, et al. [65] reported that chronic inflammation induced in the AOM + DSS mouse model of CAC was associated with an increase in amount of lymphoid tissue in the colon mucosa and the development of intratumor tertiary lymphoid structures with highly compartmentalized B-cells, T-cells, mature dendritic cells and a network of CD21+ follicular dendritic cells. This evidence concerns the gene CR2 and infectious otitis media.