S100A8 and colitis: First, responses of these DEGs were routinely more robust in mice fed TWD than AIN during colitis, as noted for genes associated with interferon response (Ifna1, Ifnb1, Ifng, Nos2), inflammation (Il1a, Il4, Il6, Il17f, Il12b, TNF, Nlrp3, S100a8), and chemokines and their receptors (Ccl3, Ccr7, Cxcl10, Cxcr4, Csf3, Csf3r), among others.