Other inhibitor compounds relevant to HCC, for which preclinical studies have been published, include gefitini [37] EGFR tyrosine kinase inhibitor and FTY720, the PI3K inhibitor, which by downregulating the Rac GTP levels, suppresses the motility of the metastatic H2M HCC cell line [38]. This evidence concerns the gene AKT1 and hepatocellular carcinoma.