For example, Pang et al. reported that ECM stiffness modulated the TGF-β1 activation and thus promoted the advancement of HCC [7]; Zhao et al. and Dong et al. suggested that ECM stiffness acted as initiators to modulate the development of HCC [8] and HCC angiogenesis via regulated the expression of integrin β1 [9]. The gene discussed is TGFB1; the disease is hepatocellular carcinoma.