While HSCT is mostly necessary for AR complete IFN-γR deficiencies, there also have been two patients reported with particular forms of AR IFN-γR deficiency affecting the first initiation codon, c.2T>A for partial recessive (PR) IFNγR1 deficiency and c.1A>G for IFNγR2 deficiency, who suffered from disseminated mycobacterial infectious diseases requiring aggressive antibiotic therapy and HSCT [26,32]. Here, IFNGR1 is linked to mycobacterial infectious disease.