IFNG and Mendelian susceptibility to mycobacterial diseases: As of now, mutations in 15 genes (IFNGR1, IFNGR2, STAT1, IL12B, IL12RB1 IL12RB2, IL23R, RORC, IRF8, ISG15, TYK2, JAK1 SPPL2A, CYBB and NEMO) have been described in the context of isolated or syndromic MSMD that cause either a disruption of the production of IFN-γ or of the reaction to IFN-γ [20,23,24,25,26].