The effect of NaSH on mRNA level of RKIP in a setting of IR injury has not been previously reported; however the positive effect of NaSH on protein kinase C (PKC) activation [73] (upstream pathway of RKIP) and negative effects on mitogen-activated protein kinase (MAPK) activation and NF-κB translocation [24] (downstream pathways of RKIP) following myocardial ischemia have been reported. The gene discussed is WNK2; the disease is myocardial ischemia.