Overall, immunocompetent patients were older (56.5 (16) vs. 51 (32) in years, p = 0.044), had an increased risk for liver failure (n = 6, 46% vs. n = 1, 2%, p < 0.001) and overall mortality (n = 4, 31% vs. n = 2, 4%, p = 0.016), had higher serum IgG concentration (13.1 (6.9) vs. 8.9 (5.3) g/L, p = 0.011) and higher HEV IgA S/CO (4.63 (2.75) vs. 1.33 (3.73), p = 0.012) than immunosuppressed patients in our cohort. Here, CD79A is linked to liver failure.