We found that IL-27, a cytokine of the IL-12 family [7,8,9], produced by myelomonocytic cells, shares several effects with IFN-γ such as the induction of IDO1, PD-L1 [10], and IL-18BP [11], in human epithelial ovarian cancer (EOC) cells. This evidence concerns the gene IFNG and ovarian carcinoma.