In female BALB/c mice, after induction of systemic lupus erythematosus (SLE)-like disease, feeding with a saleable EVOO picual variety, containing high amounts of phenolics (600 ppm), exerted a protective role in the management of such autoimmune disease, likely through the inhibition of MAPK, JAK/STAT, and NF-κB pathways in splenocytes [96]. The gene discussed is NFKB1; the disease is systemic lupus erythematosus.