In female BALB/c mice, after induction of systemic lupus erythematosus (SLE)-like disease, feeding with a saleable EVOO picual variety, containing high amounts of phenolics (600 ppm), exerted a protective role in the management of such autoimmune disease, likely through the inhibition of MAPK, JAK/STAT, and NF-κB pathways in splenocytes [96]. Here, SOAT1 is linked to systemic lupus erythematosus.