APP and early-onset autosomal dominant Alzheimer disease: Interestingly, RIP1/RIP3 seem to mediate the necroptosis of dopaminergic neurons in a murine Parkinson’s disease (PD) model [4] and PMEL amyloid formation is based on cleavage by BACE-2 and γ-secretase [2], both enzymes also capable of cleaving the Alzheimer’s disease (AD)-relevant amyloid precursor protein (APP).