MC4R and neuroblastoma: DNAJB2b has been demonstrated to modulate rhodopsin processing in neuroblastoma cells [110], to facilitate the proteasomal degradation of cystic fibrosis transmembrane conductance regulator (CFTR) through the ER-associated degradation (ERAD) pathway [111], and to reduce the total and cell-surface levels of melanocortin 4 receptor (MC4R) in a cotransfection setup [124].