The reported pathological features in all HSPB8-related myopathies have been similar: dystrophic changes and MFM pathology with protein aggregates (desmin, myotilin, CRYAB, dystrophin, HSPB8, DNAJB6, myotilin, BAG3, TDP-43, and ubiquitin) and rimmed vacuoles [438,439,440,441]. The gene discussed is CRYAB; the disease is myopathy.