As a consequence of placental ischemia, oxidative stress is augmented with an excessive release of placental factors, such as STB knots/debris, soluble fms-like tyrosine kinase-1 (sFlt-1), the soluble receptor for vascular endothelial growth factor (VEGF) into the maternal circulation, which collectively contribute to the development of hypertension [29,30]. The gene discussed is VEGFA; the disease is Hypertension.