The production of inflammatory cytokines such as IL-6, IL-8, and monocyte chemoattractant protein-1 (MCP-1) in both, human hFOB 1.19 and murine M3T3-E1 osteoblasts was increased upon the interaction with metastatic MDA-MB-231 breast cancer cells [48]. This evidence concerns the gene CCL2 and breast cancer.