The same group further extended the study by stratifying ACPA-positive RA patients into 17 subsets based on their profiles of different ACPA specificities (α-enolase, vimentin, fibrinogen, and collagen type II), which revealed the strongest association of SE, PTPN22, and CS in the subset of patients with antibodies to citrullinated α-enolase and vimentin [133]. The gene discussed is PTPN22; the disease is rheumatoid arthritis.