HLA-DRB1 and rheumatoid arthritis: As for the effects of CS, Bidkar et al. showed that CS exposure induced IFN-γ secretion from splenocytes of humanized transgenic (Tg)-mice carrying RA-susceptible HLA-DRB1*0401, while CS exposure augmented Th2 response in Tg-mice carrying RA-resistant HLA-DRB1*04:02.