In the second case, two phase-2 clinical trials (ClinicalTrials.gov Identifiers NCT02941822 and NCT02914366) have been started in patients with PD and PDD to investigate ambroxol, which is a mucolytic molecule with chaperon properties that was demonstrated to enhance GCase activity and reduce α-synuclein phosphorylation at Serine-129 in mice and non-human primates [32]. This evidence concerns the gene SNCA and Parkinson disease.