However, this hypothetical panel should include not only biomarkers that are strictly related to PD pathophysiology (e.g., α-synuclein, lysosomal enzymes, LRRK2, DJ1, and inflammatory markers), but also those biomarkers that are more involved in PD progression (e.g., Aβ42, tau proteins and NfL). This evidence concerns the gene SNCA and Parkinson disease.