The highest dose of 6K-F17 tested (128 μg/mL) decreased the PAO1 growth by over 80% on F508del-CFTR cells, confirming, for the first time, the ability of 6K-F17 to exhibit antimicrobial activity against P. aeruginosa bacteria that were grown atop HBE cells (Figure 1; grey bars) and highlighting the difficulty in eliminating infections on top of F508del-CFTR cells vs. WT-CFTR cells. The gene discussed is SMOX; the disease is infection.