ARH1 phosphorylation, at Tyr-4 and Tyr-19, was identified in a highly metastatic hepatocellular carcinoma (HCC) cell line, MHCC97H, but not in a nonmetastatic HCC cell line, Hep3B, implying that tyrosine phosphorylation of ARH1 was associated with HCC metastasis [42]. The gene discussed is LDLRAP1; the disease is hepatocellular carcinoma.