It recalled the role of Ret/ELE1 fusion (an androgen receptor activator of Ret/PTC3 transcription) as well as the importance of ESR1 and ESR2 (estrogen receptor) expression in the proliferation of tumor thyroid cells (these being stimulated by an ESR1 agonist, reduced by ESR2 expression or by an ESR2 agonist) [34]. The gene discussed is ESR2; the disease is neoplasm.