BRAF and thyroid gland papillary carcinoma: The publication of Shen, X. et al. [46] underlined that the long-observed age-associated mortality risk in PTC is dependent on the BRAF status; age is a strong, continuous, and independent mortality risk factor in patients with BRAF V600E mutation but not in patients with wildtype BRAF. These results question the conventional general use of patient age as a high-risk factor in PTC and call for differentiation between patients with BRAF V600E and wildtype BRAF when applying age to risk stratification and management of papillary thyroid cancer.