APA recognizing GH-secreting cells have been detected not only in children with idiopathic GHD but also in some children with idiopathic short stature (ISS) without GHD but whom subsequently develop this deficiency, suggesting that the detection of APA in children with ISS could identify those prone to subsequently developing an autoimmune GHD [18] (Table 1A). The gene discussed is GH1; the disease is short stature due to GHSR deficiency.