Treatment of miR-101a agomir + oe-KDM3A showed increased fibrosis degree of kidney tissues in UUO mice when compared to miR-101a agomir + oe-NC treatment, indicating that overexpression of KDM3A could reverse the inhibitory effect of upregulated miR-101a on renal fibrosis. This evidence concerns the gene KDM3A and renal fibrosis.