Emerging evidence has found that histone demethylases (KDMs), the key regulators in histone modifications, such as KDM3A, KDM5C, KDM6A, and KDM6B, can promote renal cell carcinoma (RCC) progression via hypoxia-mediated angiogenesis pathways.10 This evidence concerns the gene KDM5C and renal cell carcinoma.