SYT1 and early-onset autosomal dominant Alzheimer disease: It has been reported that SYT1 was required for rapid neurotransmitter release in mouse hippocampal neurons (Evans, Ruhl, & Chapman, 2015)and was decreased in several brain regions and increased in cerebrospinal fluid of patients with Alzheimer's disease (Ohrfelt et al., 2016; Yoo, Cairns, Fountoulakis, & Lubec, 2001).