In some specific regions of 3’ UTR of the exosomal SOX2, the NSC clones showed a 100% identity to the reported SOX2 gene (Gene ID: 6657), but SH-SY5Y, GBM and CD133+ GBM derived exosomes displayed SNP and single nucleotide insertions. The gene discussed is PROM1; the disease is glioblastoma.