These findings are significant since in our exosomal DNA analysis, we have found that NSC, SH-SY5y, GBM, and CD133+ GBM cell-derived exosomal SOX2 has miR-126 binding sites, both, site-A (1479–1500) and site-B (1744–1764) along with miR-522 binding site (1635–1657) as reported by Otsubo et al. The cellular SOX2 DNA for GBM and CD133+ GBM have all the 3 miRNA binding sites, but CD133+ GBM has an SNP in binding site-A (G > A) at position 1495 (Chromosomal position 181713418). This evidence concerns the gene PROM1 and glioblastoma.