ACHE and dementia: This finding could be explained by the use of structural (thickness) vs functional (hypometabolism) outcome measures48 or by differences in disease stage because education is possibly most beneficial in early clinical stages of AD.49 Furthermore, the effect sizes of BR and CR in the present study were small (range, 0.15-0.30),50 although only marginally smaller than those reported for treatment with acetylcholinesterase inhibitors—the current standard of care in MCI due to AD and early AD dementia—for cognitive (Cohen d = 0.29-0.51)51,52 and functional (Cohen d = 0.26)52 outcomes.