This finding aligns well with the literature because APOE-ε4 carriers have selective vulnerability of the medial temporal lobe and subsequent memory impairment, whereas APOE-ε4–negative patients with AD more often have cortical-predominant atrophy patterns in conjunction with nonamnestic cognitive deficits.56,57,58,59 Furthermore, we found no association between APOE-ε4 status and BR. Here, APOE is linked to Cognitive impairment.