ESR1 and neoplasm: However, no further significant correlations were found between germline mutation status and other clinicopathologic factors, including tumor size (P=0.561), lymph node status (P=0.731), grade (P=0.420), histology (P=0.973), ER status (P=0.733), PR status (P=0.673), HER2 status (P=0.514) and a triple-negative phenotype (P=0.416).