CHEK2 and cancer: In contrast, the recent survey by Sun et al. revealed a mutation rate of 2.9% (237/8085) and 1% (83/8085) in beyond BRCA1/2 genes and other cancer susceptibility genes, including mutations in PALB2 (n=56), TP53 (n=38), ATM (n=31), RAD51D (n=31), RECQL (n=30) and CHEK2 (n=27) among the most frequent [25].