Enriched cancer hallmark gene signature in breast cancer cells grown with supplemented aqueous EGF, HP-B hydrogel and HP-B hydrogel with solid-phase EGF compared to control. Pathways are significantly (*p < 0.05, **p < 0.005, ***p < 0.0005) altered with and without solid-phase GF presentation. The gene discussed is EGF; the disease is breast cancer.