While this result is pending of further analysis by mass spectrometry, it is tempting to say that endogenous collagen produces continuous DDR1 phosphorylation and signaling in these tumor cells, which may indicate a potential positive loop between DDR1 signaling and collagen type I. Alternatively, other collagen receptors may result altered in response to DDR1 silencing. Here, ITGA2 is linked to neoplasm.