However, it is also important to stress that Cav3 loss in muscle cells induced by the above approaches has been shown to impair myoblast fusion and differentiation.37, 38, 39 Consequently, a potential limitation of the in vitro studies reported here is that because they were performed in myoblasts, this may have translational implications for understanding how muscle physiology is affected in patients presenting with caveolinopathies, such as LGMD1C. This evidence concerns the gene CAV3 and caveolinopathy.