PROS1 and colonic neoplasm: By contrast with these observations, we found an upregulation of cell‐cycle‐related proteins (c‐Myc and Cyclin D1) in LA‐treated A549 cells in this study (Fig. S3) and found an activation of Akt by LA in this study (Fig. S2) and in previous reports [19], suggesting that the LA‐induced decrease of A549 cell viability may be through the mechanisms different from the aforementioned studies in human colon cancer cells, hepatoma cells and squamous cell carcinoma cells [17, 30, 31].