To investigate whether CDKN2C was a downstream functional factor involved in miR‐21‐5p regulating cell proliferation and cell‐cycle G1/S transition in melanoma, we performed rescue experiments by cotransfecting miR‐21‐5p mimic and pcDNA‐CDKN2C into A375 cells. The gene discussed is CDKN2C; the disease is melanoma.