We further found a large set of tight junction proteins as YAP interactors (e.g., Patj, Amotl1, Cgn, Magi1, Magi3, Mpp5, Mpdz, Tjp1, Tjp2, Tjp3) that may be involved in sensing mechanical or geometrical properties of BC. The gene discussed is PATJ; the disease is breast cancer.