Conversely, no study up-to-date evaluates adequately its role in hematologic malignancies; Xie et al. [21] explored the expression of CD146 in pediatric B-cell ALL compared to its counterpart in adults and found it to be related positively to CD64 and CD117 in adults, while in children's B-ALL, CD146 was positively related to CD71 and CD58 (P < 0.05). The gene discussed is MCAM; the disease is precursor B-cell acute lymphoblastic leukemia.