KRAS and colorectal carcinoma: These promising results with the use of synergistic combination led to the initiation of the NCT01988896 phase Ib dose-escalation and dose-expansion trial that included a cohort of patients with refractory KRAS-mutant CRC, including pMMR-MSI-L CRC but no dMMR-MSI-H CRC, who were treated with the combination of Cobimetinib and Atezolizumab [187].