As shown in Figure 1, PMQ significantly reduced the body weight and body weight gain (Figures 1(a) and 1(b)), waist circumference (Figure 1(c), and the LEE index (Figure 1(d)); lowered fasting blood glucose (Figure 1(e)) and serum insulin levels (Figure 1(f)); and ameliorated insulin resistance in MSG-IO mice (Figure 1(g)). The gene discussed is INS; the disease is Insulin resistance.