Plenty of studies over the past decades have shown that resveratrol downregulated thyroid cancer stem cell markers (including aldehyde dehydrogenases (ALDH), SOX2, OCT4, and NANOG), decreased proliferation and invasiveness, induced apoptosis, reduced ALDH-associated cancer cell stemness, and upregulated thyroid differentiation markers TTF-1 and NIS, which contributed to radioiodine uptake in the treatment of aggressive thyroid cancers [30]. This evidence concerns the gene POU5F1 and thyroid gland carcinoma.