The first hypothesis for the association of helminths with protection from severe malaria was that helminths led to an increase in IgE complexes that activated the CD23 and thus releases the anti-inflammatory IL10 and activated the inducible nitric oxide synthase, which led to the release of nitric oxide (NO) and reduced sequestration of parasitized red blood cells [33]. This evidence concerns the gene FCER2 and malaria.