CD40LG and malaria: Chronic helminth infection may enforce crossregulatory effects on the development of proinflammatory response to initial Plasmodium infection and skewed antiplasmodium antibody response towards the production of noncytophilic immunoglobulins (IgG2, IgG4, and IgM) ineffective against malaria instead of cytophilic ones necessary for immunity of malaria (IgG1 and IgG3).