Autoantibodies against cathepsin F (CTSF), cadherin-13 (CDH13), and phospholipase D4 (PLD4) were identified in six AD patients, with an average of 2.3, 2 and 1 unique peptide per patient, respectively (Table 2 andExtended Data: Supplementary Table 216). This evidence concerns the gene CTSF and Alzheimer disease.