Furthermore, to assess the relationship between NOX2 activation and systemic oxidative stress, we evaluated the serum 8-iso-prostaglandin F2α (8-iso-PGF2α), stable end products of lipid peroxidation of arachidonic acid, that have been found elevated in a number of conditions such as cardiovascular and neurodegenerative diseases [17] and serum H2O2. This evidence concerns the gene CYBB and neurodegenerative disease.