Our study revealed, for the first time, that the C. cicadae mycelium extract regulates inflammatory responses in a cisplatin-induced AKI animal model by inhibiting renal pathologic changes, inflammatory cell infiltration, and the release of a variety of proinflammatory cytokines (i.e., TNF-α, IL-1β, and IL-6). The gene discussed is IL6; the disease is acute kidney injury.