The herb-derived compound, Britanin, selectively binds to a conserved cysteine residue, cysteine 151, of Keap1 and reduces Keap1-mediated ubiquitination of Nrf2, which results in activation of the Nrf2 pathway and attenuating cerebral ischemia-reperfusion-induced damage [42] (Table 2). This evidence concerns the gene NFE2L2 and brain ischemia.