The herb-derived compound, Britanin, selectively binds to a conserved cysteine residue, cysteine 151, of Keap1 and reduces Keap1-mediated ubiquitination of Nrf2, which results in activation of the Nrf2 pathway and attenuating cerebral ischemia-reperfusion-induced damage [42] (Table 2). Here, NFE2L2 is linked to Cerebral ischemia.