In a transgenic murine model ((Thy-1)-h[A30P]-α-synuclein) with SOD2 haplodeficiency, at 1 year and 4 months, exhibiting significant features of synucleinopathy compared full SOD2 control, the results indicate that an elevated level of OS could mediate the progression of PD [142]. Here, SOD2 is linked to Parkinson disease.