PRKN and Parkinson disease: It has been shown that DA quinones have the ability to shape proteins which subsequently may be involved in PD pathophysiology, for example, α-synuclein, parkin, protein deglycase DJ-1, and ubiquitin carboxy-terminal hydrolase L1, in α-synuclein DA quinone modifying its monomer by promoting the conversion to a cytotoxic protofibril form [139].