As expected, the ROC curve suggested that the optimum cutoff value of serum GP73 for identifying participants with inflammation at moderate activity (G ≥ 2) and/or severe activity (G = 3) in this NASH cohort was 94.57 ng/ml, with the corresponding AUROC as 0.742 (95% CI: 0.676–0.801, with sensitivity of 44.74% and specificity of 92.80%) for moderate activity (G ≥ 2), which was significantly higher than that of ALT and AST (ALT: 0.609, AST: 0.667, P = 0.01). This evidence concerns the gene GOLM1 and metabolic dysfunction-associated steatohepatitis.