Migraineurs usually have positive family anamnesis, sedentary lifestyle with obesity and metabolic syndrome, significant subclinical markers of atherosclerosis including higher levels of platelet aggregation, von Willebrand factor and higher prevalence of hypercoagulable states, and more frequent major cardiovascular risk factors [3, 6–9]. Here, VWF is linked to obesity due to melanocortin 4 receptor deficiency.