Since immunochemistry analysis of CCBE1 in CRC tissues showed strong staining in the stroma and CCBE1 mRNA levels were positively associated with the expression signatures of CAF markers, including ACAN, αSMA, CDH13, DKK3, TAGLN, and TGM2 29 (Figure S1H), we explored whether CAFs express and secrete CCBE1. Here, ACAN is linked to colorectal carcinoma.