Because CCBE1 is an embryonic lymphangiogenesis factor, we next analyzed whether tumor stromal CCBE1 expression correlates with tumor lymphangiogenesis in CRC using an antibody against podoplanin (PDPN), a marker of LECs, to indicate the lymphatic vessel density in 33 CRC biopsies 28. The gene discussed is CCBE1; the disease is colorectal carcinoma.