VEGFC and colorectal carcinoma: By mixing the supernatants of HCT116 or SW480 cells with those of 293T cells, we found that pro-VEGFC (29/31 kDa) in the supernatant was largely reduced and processed to the mature form (19/21 kDa) after CCBE1 overexpression (Figure 1A), while less mature VEGFC was detected after CCBE1 knockdown (Figure 1B), indicating that CCBE1 secreted by CRC cells participates in the processing of VEGFC secreted by other cell types.