For instance, the combination of Adseverin and Transglutaminase-4 can distinguish BPH and PCa patients; while the combination of CD63, Putative glycerol kinase 5, N-sulphoglucosamine sulphohydrolase, PSA, Prostatic acid phosphatase can separate high- and low-grade PCa104. Here, CD63 is linked to posterior cortical atrophy.