ZNF471 and esophageal squamous cell carcinoma: ZNF471 methylation was detected in 92/147 (62.6%) tumors but only 22/89 (24.7%) paired adjacent non-tumor tissue samples, and 0/3 (0%) normal esophageal tissues (Fig. 1F) (Table 1), thus suggesting that ZNF471 methylation is a common event in ESCC.