In line with its important role in cellular metabolism and adhesive signaling, overexpression of CD98hc has been detected in solid and hematological human malignancies, including colorectal cancer 20, non-small cell lung cancer (NSCLC) 21, 22, triple-negative breast cancer 23, 24, metastatic prostate cancer 25 as well as lymphoma 26 and leukemia 15, 22. Here, SLC3A2 is linked to non-small cell lung carcinoma.