For hyperglycemia, specific DEMs including cadherin-5 (CADH5) 28, corticosteroid-binding globulin (CBG) 29, and a polypeptide from serotransferrin (TRFE) 30 have been reported to be associated with either elevated blood glucose, T2D or insulin resistance. The gene discussed is CDH5; the disease is type 2 diabetes mellitus.