JAK2 and ischemia: Amani et al. [38] revealed that many inflammatory and metabolic signaling pathways are involved in cell fate following ischemia/reperfusion injury, such as hippo, ubiquitin-proteasome system (ERK5), Tsc1/Tsc2 complex, FoxO1, wnt/β-catenine, Adamts1, and Jak2/stat3 signaling pathway.