The polymorphisms of IFN-γ+874 A allele was observed with significantly greater frequency in 65 Chinese patients with EV71-infected encephalitis (76.2%) compared with HFMD patients without complications (61.1%, p < 0.01, [15]), which implying that IFN-γ+874 A allele is associated with susceptibility to EV71 encephalitis in Chinese patients. This evidence concerns the gene IFNG and hand, foot and mouth disease.