IL10 and hand, foot and mouth disease: On the other hand, the IL-10-592 C allele was observed with higher frequency with critical EV71 infection (70.59%) compared with severe EV71 infection (41.43%, p < 0.01) and mild EV71 infection (43.81%, p < 0.01) [40], while IL-10-1082 A allele has greater frequency with EV71 encephalitis (86.2%) compared with HFMD patients without complications (77.0%, p < 0.05, [15]).