IL27 and hand, foot and mouth disease: Our previous study [44] found that serum IL-27 levels were distinctly higher in clinical stage III (early cardiopulmonary failure) EV71-infected HFMD patients than in clinical stage II (involvement of the nervous system) or clinical stage IV (cardiopulmonary failure) EV71-infected patients, which suggested that IL-27 may play a role in HFMD caused by EV71 infection, especially in patients with early cardiopulmonary failure.